Associação genômica ampla para identificação de genes candidatos relacionados com metabólicos proteícos em ovinos Santa Inês.

Abstract

Albumin and urea serum levels are used as clinical indicators, as well as to evaluate the nutritional status of an animal. Thus, the present study aims to performer a genome wide association study (GWAS) to identify candidate genes for albumin and urea levels in Santa Ines sheep. The GWAS analysis was performed with 320 lambs and 43,996 SNPs, using the ssGBLUP method. Regions that explain at least 1% of the genetic variance of the albumin and urea levels were discussed. Eight genomic regions explained 11.6% of the genetic variance in albumin level and the candidate genes ALDH7A1, GAPDHS, STRAP, MGTS1, EI24, HAMP, PTPRO, FFAR1, FFAR2, FFAR3, KIRREL2, ITGA8, NPHS1, TYROBP, MAG, DIABLO, PRODH2 and HPD were found. Seven genomic regions explained 12.4% of the genetic variance in urea level, and the candidate genes PCDH9, AZGP1, LAMTOR4, SMURF1, RAB31, ARPC1A, ARPC1B, CNTN1, PDZRN4, NDUFV2, CLOCK and NMU were identified. The genes found in the current study are involved in biological processes related to hepatic and renal functions and variants in these genes can be useful for breeding schemes in Santa Ines sheep.