Preparação de compostos nitrogenados e aplicação da quimiometria para maior eficiência da mecanoquímica na síntese de intermediários sintéticos.

Abstract

cinnamal)thiocarbohydrazone) obtained by wet method with 74% yield. Furthermore, bisthiocarbohydrazones were prepared via mechanochemistry, which achieved yields of 54% to quantitative, shorter reaction time, and E-factor 225 times lower than previous works. From the bisthiocarbohydrazones three new bistetrazoles were prepared using bismuth as the inorganic thiophile. The application of chemometry in organic synthesis was evaluated by the number of publications from 2014 to 2020, where it was observed that the number of publications is still incipient in this topic. To contribute to this theme, chlorinated derivatives of acetanilide were obtained via mechanochemistry and the use of chemometry to optimize the process. This type of approach has shown increasing use in organic synthesis, due to its effectiveness in product yield optimization.