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metadata.dc.type: | Artigo de Periódico |
Title: | Metabólitos secundários das esponjas Aplysina fistularis e Dysidea sp. e atividade antituberculose da 11-cetofistularina-3 |
Other Titles: | Química Nova |
Authors: | Gandolfi, Renata C. Medina, Marina B. Berlinck, Roberto Gomes de Souza Lira, Simone Possedente de Galetti, Fabio Cícero de Sá Silva, Célio L. Veloso, Katyuscya Ferreira, Antonio G. Hajdu, Eduardo Peixinho, Solange |
metadata.dc.creator: | Gandolfi, Renata C. Medina, Marina B. Berlinck, Roberto Gomes de Souza Lira, Simone Possedente de Galetti, Fabio Cícero de Sá Silva, Célio L. Veloso, Katyuscya Ferreira, Antonio G. Hajdu, Eduardo Peixinho, Solange |
Abstract: | The present investigation reports the isolation of aeroplysinin-2, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-trimethyletanamonium, 7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-carboxylic acid and its methyl ester, 11-oxoaerothionin, aerothionin, 11-keto-12-hydroxyaerothionin, 11-ketofistularin-3 and fistularin-3 from Aplysina fistularis, as well as of furodysinin lactone and 9α,11α-epoxicholest-7-en-3β,5α,6α,10-tetrol-6-acetate from Dysidea sp. Although the extracts of both sponges displayed antituberculosis activity, only 11-ketofistularin-3 isolated from A. fistularis displayed antimycobacterial activity against Mycobacterium tuberculosis H34Rv, with MIC at 16 μg/mL and SI of 40, a result that reinforce that fistularin-3 derivatives are interesting leads for the development of antituberculosis drugs. |
Keywords: | marine sponge Aplysina fistularis Dysidea sp |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/3766 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico (Biologia) |
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