1. Universidade Federal da Bahia
  2. Escola Politécnica
  3. Programa de Pós-Graduação em Engenharia Industrial (PEI)
  4. Tese (PEI)
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/36258
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Campo DCValorIdioma
dc.creatorVeloso , Gabriela Brasil Romão-
dc.date.accessioned2022-11-04T15:03:28Z-
dc.date.available2022-11-04T15:03:28Z-
dc.date.issued2022-10-03-
dc.identifier.urihttps://repositorio.ufba.br/handle/ri/36258-
dc.description.abstractIonic liquids are non-volatile organic salts that, under standardized conditions, remain in a liquid state and are composed of organic cations and organic or inorganic anions. They have a wide industrial application and sustainable profile and, generally, they are called as "green solvents", however, despite this denomination, there is insufficient information about their aspects related to their toxicity to the environment and to humans. In this context, this work aimed to evaluate the toxicological aspects of some ionic liquids through in vitro bioassays, in addition to trying to understand their effects on cells, seeking possible biological applications. For this purpose, seventeen protic ionic liquids were synthesized and analyzed by in vitro assays of: cytotoxicity in metabolizing cells (HepG2) and skin cells (HaCat and HDFa); morphological observation of HaCat cells exposed to these liquids; and eye irritation in chicken egg's chorioallantoic membrane (HET-CAM). In order to study a possible biological application, the wound healing potential in HDFa cells was also evaluated. The results obtained were promising, since, in general, the ionic liquids showed a low cytotoxic effect, obtaining IC50 values between 8 and 390 mM, approximately. In addition, it was possible to observe its effect on cells, causing an increase or decrease in volume and/or rupture of cell membrane in HaCat cells, due to osmotic pressure. The eye irritation test showed that the ionic liquids composed of citric acid did not cause eye irritation, while thirteen of them were characterized as mild or moderate irritants, and it is possible to suggest, based on this test, their safe use in living organisms, although there are reservations. It was also confirmed, from a quantitative analysis by the ImageJ software, the classification of eye irritation by the analysis of grayscale images. In addition, no sample tested was able to prevent the healing process evaluated in vitro, which is another indication of safety and, still, the ionic liquid based on oxalic acid stands out for being able to improve cell migration. Therefore, it was possible to conclude that the protic ionic liquids evaluated in this work are, in general, safe, less toxic to human cells than conventionally used solvents and the collected results contribute significantly to science, as they indicate safety parameters of these compounds, related to their chemical characteristics and concentrations and reinforce the need to continue these studies. Also, in this work, a new direction of research is suggested using protic ionic liquids, seeking biological effects for them.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado da Bahia - Fapesbpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal da Bahiapt_BR
dc.subjectLíquidos iônicos próticospt_BR
dc.subjectToxicidadept_BR
dc.subjectCélulaspt_BR
dc.subjectCicatrizaçãopt_BR
dc.subject.otherProtic ionic liquidspt_BR
dc.subject.otherToxicitypt_BR
dc.subject.otherCellspt_BR
dc.subject.otherWound healingpt_BR
dc.titleEstudo de segurança de líquidos iônicos próticos à saúde humana: uma alternativa aos solventes convencionaispt_BR
dc.title.alternativeSafety study of protic ionic liquids to human health: an alternative to conventional solventspt_BR
dc.typeTesept_BR
dc.publisher.programPrograma de Pós-Graduação em Engenharia Industrial (PEI) pt_BR
dc.publisher.initialsUFBApt_BR
dc.publisher.countryBrasilpt_BR
dc.subject.cnpqCNPQ::OUTROS::QUIMICA INDUSTRIALpt_BR
dc.contributor.advisor1Iglesias Duro , Miguel Angel-
dc.contributor.advisor1ID0000-0002-5897-0152pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1626030153202401pt_BR
dc.contributor.advisor-co1Andréo, Bruna Galdorfini Chiari-
dc.contributor.advisor-co1ID0000-0001-7959-0207pt_BR
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/6153974945085893pt_BR
dc.contributor.referee1Iglesias Duro, Miguel Angel-
dc.contributor.referee1ID0000-0002-5897-0152pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/1626030153202401pt_BR
dc.contributor.referee2Andrade, Rebecca da Silva-
dc.contributor.referee2ID0000-0001-8915-7220pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/4299693971980688pt_BR
dc.contributor.referee3Eliane, Trovatti-
dc.contributor.referee3ID0000-0002-0495-8115pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/0001438935762110pt_BR
dc.contributor.referee4Rillo Sato, Mariana-
dc.contributor.referee4ID0000-0002-6527-3937pt_BR
dc.contributor.referee4Latteshttp://lattes.cnpq.br/2070935538667643pt_BR
dc.contributor.referee5Oshiro, João Augusto-
dc.contributor.referee5ID0000-0001-7247-1598pt_BR
dc.contributor.referee5Latteshttp://lattes.cnpq.br/7718234509377672pt_BR
dc.creator.ID0000-0001-8984-2869pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4908934995460369pt_BR
dc.description.resumoLíquidos iônicos são sais orgânicos não voláteis que, em condições normalizadas, permanecem em estado líquido e são compostos por cátions orgânicos e ânions orgânicos ou inorgânicos. Apresentam uma vasta aplicação industrial e perfil sustentável e, geralmente, são chamados de “solventes verdes”, porém, apesar desta denominação, ainda há informações insuficientes sobre seus aspectos relacionados à sua toxicidade ao meio ambiente e aos seres humanos. Neste contexto, este trabalho teve como objetivo avaliar os aspectos toxicológicos de alguns líquidos iônicos através de bioensaios in vitro, além de tentar compreender seus efeitos em células, buscando possíveis aplicações biológicas. Para isso foram sintetizados dezessete líquidos iônicos próticos e analisados em ensaios in vitro de: citotoxicidade em células metabolizadoras (HepG2) e células de pele (HaCat e HDFa); de observação morfológica de células HaCat em exposição a esses líquidos; e de irritação ocular em membrana cório-alantóide de ovos fecundados de galinha (HET-CAM). Visando estudar uma possível aplicação biológica, o potencial de cicatrização em células HDFa também foi avaliado. Os resultados obtidos foram promissores, uma vez que, em geral, os líquidos mostraram baixo efeito citotóxico, obtendo valores de CI50 entre 8 e 390 mM, aproximadamente. Além disso, foi possível observar seu efeito sobre as células, ocasionando aumento ou diminuição de volume e/ou ruptura da membrana celular em linhagem HaCat, devido à pressão osmótica. O ensaio de irritação ocular demonstrou que os líquidos iônicos compostos de ácido cítrico, não ocasionaram irritação ocular, enquanto treze deles foram caracterizados como irritantes leves ou moderados, sendo possível sugerir, baseando-se neste teste, a sua utilização com segurança em organismos vivos, apesar de haverem ressalvas. Também foi possível confirmar, a partir de uma análise quantitativa pelo software ImageJ, a classificação de irritação ocular a partir da análise das imagens em escala de cinza. Além disso, nenhuma amostra testada foi capaz de impedir o processo de cicatrização avaliado in vitro, sendo este mais um indício de segurança e, ainda, o líquido iônico composto por ácido oxálico se destacou por ser capaz de favorecer a proliferação celular. Portanto, foi possível concluir que os líquidos iônicos próticos avaliados neste trabalho são, de maneira geral, seguros, menos tóxicos às células humanas do que solventes convencionalmente usados e os resultados coletados contribuem significativamente com a ciência, pois indicam parâmetros de segurança destes compostos, relacionados às suas características químicas e concentrações e reforçam a necessidade da continuidade destes estudos. Também, neste trabalho, sugere-se um novo rumo das pesquisas empregando líquidos iônicos próticos, buscando efeitos biológicos para os mesmos.pt_BR
dc.publisher.departmentEscola Politécnicapt_BR
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