CONDIÇÃO PERIODONTAL E FATORES RELACIONADOS À DISLIPIDEMIA

Abstract

Dyslipidemia is a disorder characterized by increased serum levels of total cholester ol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) and re duced levels of high-density lipoprotein cholesterol (HDL-C). This condition repre sents an important risk factor for cardiovascular diseases and, therefore, should be increasingly investigated. Periodontitis, like other factors, has been associated with lipid alterations. The present study aimed to evaluate the periodontal condition and identify factors related to dyslipidemia. This work was developed in two stages. In the first stage, an umbrella review study was carried out, which synthesized existing me ta-analyses on factors associated with dyslipidemia. Searches were performed on EMBASE, PubMed, Scopus, LILACS, Web of Science and Cochrane Database of Systematic Reviews. In the end, 47 studies were eligible, bringing together 808 pri mary studies, totaling 160 meta-analyses that evaluated 43 factors associated with hyperlipidemia. Only 03 of the 43 factors evaluated showed no association with any of the lipid components. In the second stage, a cross-sectional epidemiological study was carried out in 259 adult individuals treated at Health Units in Salvador, Bahia, to estimate the association between periodontitis and lipid components. For the descrip tive analysis, medians and interquartile ranges were used for continuous variables and frequencies for categorical ones. The Mann-Whitney T test was used in the biva riate analysis and variables with p<0.10 were included in the multinomial regression model. Multivariate analysis showed that TG was the only lipid associated with perio dontitis, when TG > 162mg/dl, and this association was statistically significant (OR=2.97; 95% CI=1.14-1.71). It is concluded that dyslipidemia is a multifactorial disease and is associated with periodontitis, demonstrating the importance of a mul tidisciplinary approach for the control of this lipid disorder.