Quantificação da deposição de estrôncio e análise histomorfológica, em órgãos de rato, do efeito da administração enteral de fármacos para a regeneração óssea

Abstract

Introduction: Strontium (Sr) promotes the stimulation of the metabolic effects that occur during the formation of bone tissue, stimulates osteoblasts and produces an inhibitory effect on osteoclasts, as well as the ability to replace calcium in the crystal lattice of hydroxyapatite. It has been incorporated into the structure of novel bioactive materials as well as being used as a drug in the form of strontium ranelate to increase bone density in patients with osteoporosis, rheumatoid arthritis and bone metastatic diseases. Objective: The objective of this work was to quantify by the technique of spectrophotometry with atomic absorption with graphite furnace (GFAAS) and to evaluate histologically the effect of strontium deposition in liver and kidney of rats, after enteral administration of drugs containing strontium, for the bone regeneration. Materials and methods: Wistar rats were used between 350 and 480 grams in weight, divided into groups: Protos1 (GP1), Protos 2 (GP2), Drug (GF) and Control (GC) with their biological points of 15, 30 and 60 days. Results: The histological results were histologically altered in the liver and kidney. The deposited concentrations of Sr in mouse liver were also evidenced. Conclusion: It was concluded that the histological evaluation evidenced cellular alterations in the liver and kidney, being compatible with the increase of the concentration of Sr. The degree of Sr concentration was significant for 15 and 60 days, due to the high liver deposition attesting toxicity.