Síntese de guanil-hidrazonas, 5-aminotetrazois e bis-tetrazois promovida por sais de bismuto empregando micro-ondas

Abstract

In this work, multicomponent reactions, bismuth salts, and the use of microwave as a heating source reactor were used, in order to obtain a variety of molecules, as an efficiently, versatile and green method. Thus were synthesized guanylhydrazone, 5-aminotetrazoles, bistetrazoles and its analogs using bismuth salts as inorganic thiophile, and since these reagents are green, following the synthetic current parameters. The guanylhydrazones were obtained in good yields by bicomponent reactions involving amines with different patterns of reactivity and thiosemicarbazone, catalyzed by BiI3. The use of microwave reactor as the heating source allowed a significant decrease in the reaction time. For the synthesis of 5-aminotetrazoles, bistetrazoles and its analogs, it was used a tricomponent condition allowing greater atomic economy and reducing the reaction time. The synthesis of these compounds was highly regioselective, and in most examples, only a single regioisomer was obtained.