Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/3145
metadata.dc.type: Artigo de Periódico
Title: Human-Leishmaniasis@cytokines.bahia.br
Other Titles: Brazilian Journal of Medical and Biological Research
Authors: Carvalho Filho, Edgar Marcelino de
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Brodskyn, Claudia Ida
metadata.dc.creator: Carvalho Filho, Edgar Marcelino de
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Brodskyn, Claudia Ida
Abstract: The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-g is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-g, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-g opposing cytokine, and IL-12 as an IFN-g inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-g production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-g production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4.
Keywords: Cytokines
Human leishmaniasis
Immunoregulation
IL-12
IL-10
URI: http://www.repositorio.ufba.br/ri/handle/ri/3145
Issue Date: 1998
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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