https://repositorio.ufba.br/handle/ri/3145
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Brodskyn, Claudia Ida | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Brodskyn, Claudia Ida | - |
dc.date.accessioned | 2011-10-06T13:43:59Z | - |
dc.date.available | 2011-10-06T13:43:59Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 1678-4510 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/3145 | - |
dc.description | p. 149-155 | pt_BR |
dc.description.abstract | The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-g is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-g, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-g opposing cytokine, and IL-12 as an IFN-g inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-g production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-g production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | Human leishmaniasis | pt_BR |
dc.subject | Immunoregulation | pt_BR |
dc.subject | IL-12 | pt_BR |
dc.subject | IL-10 | pt_BR |
dc.title | Human-Leishmaniasis@cytokines.bahia.br | pt_BR |
dc.title.alternative | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | 31(1) | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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