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https://repositorio.ufba.br/handle/ri/2619
metadata.dc.type: | Artigo de Periódico |
Title: | Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil |
Other Titles: | Genetics and Molecular Biology |
Authors: | Barbosa, Cynara Gomes Souza, Claudio Lima Moura Neto, José Pereira de Arruda, Maria da Glória Bomfim Barreto, José Henrique Silva Reis, Mitermayer Galvão Goncalves, Marilda Souza |
metadata.dc.creator: | Barbosa, Cynara Gomes Souza, Claudio Lima Moura Neto, José Pereira de Arruda, Maria da Glória Bomfim Barreto, José Henrique Silva Reis, Mitermayer Galvão Goncalves, Marilda Souza |
Abstract: | Methylenetetrahydrofolate reductase (MTHFR: EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows: CML = 17.2% for C677T, 21.6% for A1298C; AML-M3 = 22.2% for C677T, 24.1% for A1298C; and controls = 20.5% for C677T, 21% for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3. |
Keywords: | AML CML MTHFR polymorphisms |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/2619 |
Issue Date: | 2008 |
Appears in Collections: | Artigo Publicado em Periódico (FAR) |
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