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metadata.dc.type: Artigo de Periódico
Título : Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
Otros títulos : Revista do Instituto de Medicina Tropical de São Paulo
Autor : Geris, Regina
Silva, Ionizete Garcia da
Silva, Heloísa Helena Garcia da
Barison, Andersson
Rodrigues-Filho, Edson
Ferreira, Antônio Gilberto
metadata.dc.creator: Geris, Regina
Silva, Ionizete Garcia da
Silva, Heloísa Helena Garcia da
Barison, Andersson
Rodrigues-Filho, Edson
Ferreira, Antônio Gilberto
Resumen : The objective of this study was to evaluate the larvicidal activity of diterpenoids obtained from the oil-resin of Copaifera reticulata against Aedes aegypti larvae, the principal vector of dengue and urban yellow fever. Four diterpenes were obtained from oil-resin extraction with organic solvents and subsequent chromatographic and spectroscopic procedures allowed to isolation and identification of these compounds as 3-b-acetoxylabdan-8(17)-13-dien-15-oic acid (1), alepterolic acid (2), 3-b-hidroxylabdan-8(17)-en-15-oic acid (3), and ent-agatic acid (4). Each compound was previously dissolved in dimethylsulphoxide, and distilled water was added to obtain the desired concentrations. Twenty larvae of third instars were placed into plastic beckers, containing the solution test (25 mL), in a five repetitions scheme, and their mortality, indicated by torpor and darkening of the cephalic capsule, was recorded after 48h. Probit analyses were used to determine lethal concentrations (LC50 and LC90) and their respective 95% confidence intervals. This study showed that only diterpenoids 1 and 2 exhibited larvicidal properties with LC50 of 0.8 ppm and 87.3 ppm, respectively, revealing the former as the most toxic compound against third instars of Ae. aegypti. Therefore, this compound seems to be an interesting source for new metabolite to be exploited.
Palabras clave : Copaifera reticulata
ent-Labdane Diterpenoids
Larvicidal activity
Aedes aegypti
URI : http://www.repositorio.ufba.br/ri/handle/ri/2188
Fecha de publicación : 2008
Aparece en las colecciones: Artigo Publicado em Periódico (Química)

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