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metadata.dc.type: | Artigo de Periódico |
Title: | Phenotypic characterization and plasmid analysis of Klebsiella pneumoniae strains from Iranian patients |
Other Titles: | Revista de Ciências Médicas e Biológicas |
Authors: | Feizabadi, Mohammad Mehdi Farahani, Akram Shahrbai Rahmati, Marveh Asadi, Soroor |
metadata.dc.creator: | Feizabadi, Mohammad Mehdi Farahani, Akram Shahrbai Rahmati, Marveh Asadi, Soroor |
Abstract: | Abstract: Local knowledge of antimicrobial susceptibilities of Klebsiella pneumoniae is important for implementation of effective hospitals anti-infective policies. One hundred isolates of K. pneumoniae collected from 3 different hospitals in Iran during 2004 were screened for their susceptibilities to thirteen different antibiotics using disk diffusion test and macro broth dilution assay. Isolates were then subjected to restriction endonuclease analysis of plasmid DNA. All isolates were susceptible to imipenem. The rates of resistance to other antibiotics were in the following order: amikacin (10%), piperacillin-tazobactam (%2), ciprofloxacin (20%), ceftizoxime (14%), cefexime (31%), ceftazidime (28%), cefotaxime (33%), nalidixic acid (32%), cephalexin (32%), gentamicin (30%), nitrofurantoin (31%) and piperacillin (66%). The production of extended spectrum betalactamase (ESBL) hydrolyzing ceftazidime and cefotaxime was detected in 54% of isolates. Of 100 isolates tested, 67 harbored plasmids and the remaining lacked any plasmid. Though the prevalence of ESBL phenotype in Iran is higher than western countries, it is close to figures reported from the region. Evidences for outbreaks with certain isolates of K. pneumoniae were found by restriction endonuclease analysis of plasmid DNA. This technique also showed the persistence of infections in the urinary tract of several patients. |
Keywords: | Klebsiella pneumoniae - cepas Perfil plasmidial Hospital de Tehran Infecções nosocomiais Resistência a drogas |
Publisher: | Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
Citation: | FEIZABADI, M. M et al. Phenotypic characterization and plasmid analysis of Klebsiella pneumoniae strains from Iranian patients. R. Ci. méd. biol., Salvador, v.7, n.3, p. 273-279, set./dez. 2008. |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/20553 |
Issue Date: | Sep-2008 |
Appears in Collections: | Artigo Publicado em Periódico (PPGPIOS) |
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