https://repositorio.ufba.br/handle/ri/16651
Tipo: | Artigo de Periódico |
Título: | Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus |
Título(s) alternativo(s): | JAIDS Journal of Acquired Immune Deficiency Syndromes |
Autor(es): | Alcântara, Luiz Carlos Júnior Van Dooren, S. Gonçalves, M. S. Kashima, Simone Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Maria Inês Costa Andrade Filho, Antonio Covas, Dimas Tadeu Vandamme, Anne Mieke Castro, Bernardo Galvão |
Autor(es): | Alcântara, Luiz Carlos Júnior Van Dooren, S. Gonçalves, M. S. Kashima, Simone Costa, Maria Cristina Ramos Santos, Fred Luciano Neves Bittencourt, Achilea Candida Lisboa Dourado, Maria Inês Costa Andrade Filho, Antonio Covas, Dimas Tadeu Vandamme, Anne Mieke Castro, Bernardo Galvão |
Abstract: | The city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar to some African cities. Up to now, it has had the highest prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate which strains of HTLV-I are circulating in Salvador, we studied isolates from 82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample from a pregnant woman was closely related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I lineage into Salvador. βA-Globin haplotypes were examined in 34 infected individuals and found to be atypical, confirming the racial heterogeneity of this population. A total of 20 chromosomes were characterized as Central African Republic (CAR) haplotype (29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were characterized as Senegal (SEN) haplotype. Five patients' genotypes (14.7%) were CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 (20.6%), SEN/SEN. One patient's genotype (2.9%) was CAR/SEN. The βA-globin haplotype distribution in Salvador is unusual compared with other Brazilian states. Our data support the hypothesis of multiple post-Columbian introductions of African HTLV-Ia strains in Salvador, Bahia, Brazil. |
Palavras-chave: | β-globin haplotypes Bantu HTLV-I LTR Salvador-Brazil Southern Africa |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16651 |
Data do documento: | 2003 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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Alcantara Jr., L.C..pdf | 4,64 MB | Adobe PDF | Visualizar/Abrir |
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