Campo DC | Valor | Idioma |
dc.contributor.author | Alcântara, Luiz Carlos Júnior | - |
dc.contributor.author | Van Dooren, S. | - |
dc.contributor.author | Gonçalves, M. S. | - |
dc.contributor.author | Kashima, Simone | - |
dc.contributor.author | Costa, Maria Cristina Ramos | - |
dc.contributor.author | Santos, Fred Luciano Neves | - |
dc.contributor.author | Bittencourt, Achilea Candida Lisboa | - |
dc.contributor.author | Dourado, Maria Inês Costa | - |
dc.contributor.author | Andrade Filho, Antonio | - |
dc.contributor.author | Covas, Dimas Tadeu | - |
dc.contributor.author | Vandamme, Anne Mieke | - |
dc.contributor.author | Castro, Bernardo Galvão | - |
dc.creator | Alcântara, Luiz Carlos Júnior | - |
dc.creator | Van Dooren, S. | - |
dc.creator | Gonçalves, M. S. | - |
dc.creator | Kashima, Simone | - |
dc.creator | Costa, Maria Cristina Ramos | - |
dc.creator | Santos, Fred Luciano Neves | - |
dc.creator | Bittencourt, Achilea Candida Lisboa | - |
dc.creator | Dourado, Maria Inês Costa | - |
dc.creator | Andrade Filho, Antonio | - |
dc.creator | Covas, Dimas Tadeu | - |
dc.creator | Vandamme, Anne Mieke | - |
dc.creator | Castro, Bernardo Galvão | - |
dc.date.accessioned | 2014-11-24T15:30:48Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16651 | - |
dc.description | Texto completo: acesso restrito. p. 536-542 | pt_BR |
dc.description.abstract | The city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar to some African cities. Up to now, it has had the highest prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate which strains of HTLV-I are circulating in Salvador, we studied isolates from 82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample from a pregnant woman was closely related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I lineage into Salvador. βA-Globin haplotypes were examined in 34 infected individuals and found to be atypical, confirming the racial heterogeneity of this population. A total of 20 chromosomes were characterized as Central African Republic (CAR) haplotype (29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were characterized as Senegal (SEN) haplotype. Five patients' genotypes (14.7%) were CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 (20.6%), SEN/SEN. One patient's genotype (2.9%) was CAR/SEN. The βA-globin haplotype distribution in Salvador is unusual compared with other Brazilian states. Our data support the hypothesis of multiple post-Columbian introductions of African HTLV-Ia strains in Salvador, Bahia, Brazil. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | β-globin haplotypes | pt_BR |
dc.subject | Bantu | pt_BR |
dc.subject | HTLV-I | pt_BR |
dc.subject | LTR | pt_BR |
dc.subject | Salvador-Brazil | pt_BR |
dc.subject | Southern Africa | pt_BR |
dc.title | Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus | pt_BR |
dc.title.alternative | JAIDS Journal of Acquired Immune Deficiency Syndromes | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 33, n. 4 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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