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metadata.dc.type: | Artigo de Periódico |
Title: | Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction |
Other Titles: | International Journal of Experimental Pathology |
Authors: | Prado, Patrícia S. de Almeida Soares, Maria Fernanda Lima, Flávio O. Schor, Nestor Teixeira, Vicente P. C. |
metadata.dc.creator: | Prado, Patrícia S. de Almeida Soares, Maria Fernanda Lima, Flávio O. Schor, Nestor Teixeira, Vicente P. C. |
Abstract: | Infravesical obstruction (IVO) secondary to benign prostatic hypertrophy can affect up to 50% of men over 50 years old and may cause serious and irreversible alterations throughout the urinary tract, especially in the bladder. Therapeutic approaches are currently limited. Amitriptyline has recently been described as an analgesic, anti-inflammatory and myorelaxant in some experimental models. The objective of this study was to investigate the effects of amitriptyline hydrochloride on the process of fibrosis in a bladder outlet obstruction model in rats. Male Wistar rats were subjected to IVO and studied at intervals of 1 and 14 days postprocedure. The rats were randomly divided into five groups: sham, IVO1-T, IVO1-NT, IVO14-T and IVO14-NT. Bladder tissue was processed for histopathology, immunohistochemistry and RT-PCR. The IVO14 groups presented bladder fibrosis, smooth muscle cell hypertrophy and bladder wall thickening. The IVO14-T group demonstrated a higher intensity of fibrosis, higher macrophage infiltration rate and higher gene expression of Transforming growth factor (TGF) Tgf-β1. Thus this data shows that in this experimental mode amitriptyline had an amplifying effect on the process of fibrosis as a whole. |
Keywords: | Amitriptyline Bladder outlet obstruction Fibrosis Osteopontin Transforming growth factor-beta1 |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16221 |
Issue Date: | 2012 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Patrícia S. de Almeida Prado.pdf | 497,27 kB | Adobe PDF | View/Open |
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