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https://repositorio.ufba.br/handle/ri/15997
metadata.dc.type: | Artigo de Periódico |
Title: | Protein expression of VEGF, IGF-1 and FGF in retroocular connective tissues and clinical correlation in Graves' ophthalmopathy |
Other Titles: | Arquivos Brasileiros de Oftalmologia |
Authors: | Matos, Kimble Manso, Paulo Gois Marback, Eduardo Furlanetto, Reinaldo Alberti, Gustave Nosé Nosé, Vania |
metadata.dc.creator: | Matos, Kimble Manso, Paulo Gois Marback, Eduardo Furlanetto, Reinaldo Alberti, Gustave Nosé Nosé, Vania |
Abstract: | PURPOSE: To investigate the immunohistochemical expression (IGF-1, EGFr, EGF, c-erbB-2/HER-2/neu, PDGF-A, PDGF-B, FGF and VEGF) in patients with Graves' ophthalmopathy. METHODS: Twenty-four samples (Graves' ophthalmopathy patients) underwent lateral rectus muscle and surrounding fibrous and adipose tissue biopsy. The control group was obtained by strabismus surgery. Correlation between clinical- ophthalmologic, endocrinological, ultrasonographic findings, and immunohistochemical expression was performed. RESULTS: IGF-1: There were 7 positive cases (29.2%). There was a direct relation with higher CAS (clinical activity score) in all of them and if only CAS equal or higher than 5 was considered, this was 54.5%. FGF: There was expression in 5 cases (20.8%) with a direct relation in all those with higher CAS (>5) (45.4%). VEGF: There were two positive cases (8.3%) for VEGF in endothelial cells, in these cases the patients also presented CAS higher than 5. There was no expressions of all growth factors in the control group. CONCLUSIONS: All patients, except one, with positive expression of FGF, IGF-1 and VEGF showed CAS greater than 5, suggesting in this way an important role of these growth factors in the pathogenesis and severity of Graves' ophthalmopathy. However, statistical analysis revealed only significant association between IGF-1 and male sex (P=0.034). Low ultrasound reflectivity and endocrine status may not correlate directly with disease activity or with immunoexpression of growth factors and c-erbB-2/HER-2/neu. |
Keywords: | Imunohistochemstry Receptor, erbB-2/analysis Receptor, epidermal growth factor/analysis Insulin-like growth factor I/analysis Epidermal growth factor/analysis Platelet-derived growth factor alpha/analysis Proto-oncogene proteins c-sis/analysis Fibroblast growth factors/analysis Vascular endothelial growth factor A/analysis Graves' ophthalmopathy/metabolism |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15997 |
Issue Date: | 2008 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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File | Description | Size | Format | |
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0004-27492008000400004.pdf | 492,05 kB | Adobe PDF | View/Open |
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