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metadata.dc.type: Artigo de Periódico
Title: Hantavirus pulmonary syndrome: Prognostic factors for death in reported cases in Brazil
Other Titles: Transactions of The Royal Society of Tropical Medicine and Hygiene
Authors: Dias, Juarez Pereira
Elkhoury, Mauro da Rosa
Mendes, Wellington da Silva
Waldman, Eliseu Alves
Carmo, Eduardo Hage
Vasconcelos, Pedro Fernando da Costa
Abstract: Hantavirus pulmonary syndrome (HPS) was described for the first time in Brazil in 1993 and has occurred endemically throughout the country. This study analysed clinical and laboratory aspects as well as death-related factors for HPS cases in Brazil from 1993 to 2006. The investigation comprised a descriptive and exploratory study of the history of cases as well as an analytical retrospective cohort survey to identify prognostic factors for death due to HPS. A total of 855 Brazilian HPS cases were assessed. The majority of cases occurred during spring (33.5%) and winter (27.6%), mainly among young male adults working in rural areas. The global case fatality rate was 39.3%. The mean interval between the onset of symptoms and hospitalisation was 4 days and that between hospitalisation and death was 1 day. In the multiple regression analysis, adult respiratory distress syndrome and mechanical respiratory support were associated with risk of death; when these two variables were excluded from the model, dyspnoea and haemoconcentration were associated with a higher risk of death.
Keywords: Hantavirus
Hantavirus pulmonary syndrome
Prognostic factors
metadata.dc.rights: restrito
Issue Date: 2012
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

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