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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/15557
Tipo: Artigo de Periódico
Título: Inflammation biomarkers in chronic hepatitis C: association with liver histopathology, HCV genotype and cryoglobulinemia
Título(s) alternativo(s): Inflammation Research
Autor(es): Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
Cabral, Milena Barreto de Arruda
Santos, Gilvan
Atta, Ajax Mercês
Autor(es): Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
Cabral, Milena Barreto de Arruda
Santos, Gilvan
Atta, Ajax Mercês
Abstract: Objective: This work investigated the profile of inflammation biomarkers in patients with chronic hepatitis C and its association with liver fibrosis, hepatic necroinflammatory activity, viral genotypes and cryoglobulinemia. Subjects and methods: Seventy-eight untreated patients were studied. Biomarker levels were determined by immunoassays, cryoglobulinemia by cryoprecipitation and liver histopathology investigated using METAVIR scores. Results: Decreased levels of α1-acid glycoprotein (AGP), C3 and haptoglobin (Hp) were observed in the patients (P < 0.0001). Increased α1-antitrypsin (P < 0.01) and ferritin (P < 0.0001) levels were found in this group, but C-reactive protein (CRP) and C4 levels were unaltered. Alanine aminotransferase inversely correlated with Hp (P < 0.01) and AGP (P = 0.01), whereas it was directly correlated with ferritin (P < 0.05) and AGP (P < 0.0001). The levels of CRP, C3 and C4 were lower in the patients with hepatic necroinflammatory activity (P < 0.05). Patients with advanced fibrosis had low levels of Hp and AGP (P < 0.05 and P < 0.01, respectively). Neither infection with different viral genotypes nor cryoglobulinemia caused an alteration in biomarker levels. Conclusion: Chronic hepatitis C virus infection alters the levels of some biomarkers, which are mainly observed in patients with liver fibrosis and hepatic necroinflammatory activity.
Palavras-chave: Hepatitis C
Inflammation biomarkers
Liver histopathology
Viral genotype
Cryoglobulinemia
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/15557
Data do documento: 2012
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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