https://repositorio.ufba.br/handle/ri/15057
metadata.dc.type: | Artigo de Periódico |
Title: | Treatment of strongyloidiasis in HTLV-1 and Strongyloides stercoralis coinfected patients is associated with increased TNFα and decreased soluble IL2 receptor levels |
Other Titles: | Transactions of The Royal Society of Tropical Medicine and Hygiene |
Authors: | Salles, Fernanda Bacellar, Andrea Amorim, Mirla Orge, Glória Sundberg, Michael A. Lima, Márcia Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Salles, Fernanda Bacellar, Andrea Amorim, Mirla Orge, Glória Sundberg, Michael A. Lima, Márcia Santos, Silvane Maria Braga Porto, Maria Aurélia da Fonseca Carvalho Filho, Edgar Marcelino de |
Abstract: | Background Human T cell lymphotropic virus type 1 (HTLV-1) infection has been associated with recurrent and disseminated strongyloidiasis and adult T cell leukemia/lymphoma (ATLL). Methods We compared immunological aspects and markers for ATLL in HTLV-1 patients with or without strongyloidiasis, and evaluated the influence of Strongyloides stercoralis treatment on the immune response and clinical outcomes of HTLV-1 infection. Results Levels of TNFα and IFNγ were lower in patients coinfected with HTLV-1 and S. stercoralis than in patients with HTLV-1 only (p < 0.05), and there was an increase in TNFα levels after anthelmintic treatment. Levels of sIL-2R were higher in patients with HTLV-1 coinfected with S. stercoralis and anthelmintic treatment decreased sIL-2R levels (p < 0.05). The one patient who developed ATLL was coinfected with S. stercoralis. Conclusion These data show that helminthic infection has a modulatory role in HTLV-1 infection and that S. stercoralis may be a cofactor in the development of ATLL. |
Keywords: | HTLV-1 Strongyloides stercoralis Leukemia ATLL Interleukin-2 receptor sIL-2R Human T-lymphotropic virus 1 Leukemia-Lymphoma, Adult T-Cell |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/15057 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
File | Description | Size | Format | |
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10.1093-trstmh-trt05.pdf | 173,01 kB | Adobe PDF | View/Open |
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