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https://repositorio.ufba.br/handle/ri/14876
metadata.dc.type: | Artigo de Periódico |
Title: | Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
Other Titles: | Materials Science and Engineering: C |
Authors: | Denadai, Ângelo M. L. Silva, Jeferson G. da Guimarães, Pedro P. G. Gomes, Leonardo Bertolini S. Mangrich, Antonio S. Rezende, Edivaltrys I. P. de Daniel, Izabela M. P. Beraldo, Heloísa Sinisterra, Rubén D. |
metadata.dc.creator: | Denadai, Ângelo M. L. Silva, Jeferson G. da Guimarães, Pedro P. G. Gomes, Leonardo Bertolini S. Mangrich, Antonio S. Rezende, Edivaltrys I. P. de Daniel, Izabela M. P. Beraldo, Heloísa Sinisterra, Rubén D. |
Abstract: | Reaction of highly soluble orally active, non-peptide antihypertensive drug losartan with copper(II) leads to the spontaneous formation of a very insoluble 2:1 covalent complex, which self assembles in a hydrophobic supramolecular structure of nanometric dimensions. Thermal analysis showed that Los/Cu(II) complex presents intermediate stability in comparison with its precursors KLos and Cu(OAc)2·H2O. Isothermal titration calorimetry indicated complexation to be a stepwise process, driven by enthalpy and entropy. Zeta potential and DLS measurements showed that it is possible to control the size and charge of nanoprecipitates by adjusting the relative concentration of Los− and Cu(II). |
Keywords: | Losartan Copper Coordination complex Hydrophobic precipitate Stepwise complexation Control of size |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14876 |
Issue Date: | 2013 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0928493113003214-main.pdf | 890,98 kB | Adobe PDF | View/Open |
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