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metadata.dc.type: | Artigo de Periódico |
Title: | Sole infection by human metapneumovirus among children with radiographically diagnosed community-acquired pneumonia in a tropical region |
Other Titles: | Influenza and Other Respiratory Viruses |
Authors: | Carvalho, Cristiana Maria Costa Nascimento de Cardoso, Maria Regina Alves Ruuskanen, Olli Lappalainen, Maija |
metadata.dc.creator: | Carvalho, Cristiana Maria Costa Nascimento de Cardoso, Maria Regina Alves Ruuskanen, Olli Lappalainen, Maija |
Abstract: | Background Limited information is available on the role of human metapneumovirus (HMPV) as the unique pathogen among children hospitalized for community-acquired pneumonia (CAP) in a tropical region. Objective We aimed to describe HMPV infection among children with CAP investigating bacterial and viral co-infections. Patients and methods A prospective study was carried out in Salvador, North-East Brazil. Overall, 268 children aged <5 years hospitalized for CAP were enrolled. Human metapneumovirus RNA was detected in nasopharyngeal aspirates (NPA) by reverse transcription polymerase chain reaction. Sixteen other bacterial and viral pathogens were investigated by an expanded panel of laboratory methods. Chest X-ray taken on admission was read by an independent paediatric radiologist unaware of clinical information or the established aetiology. Results Human metapneumovirus RNA was detected in NPAs of 11 (4.1%) children, of which 4 (36%) had sole HMPV infection. The disease was significantly shorter among patients with sole HMPV infection in comparison with patients with mixed infection (4 ± 1 versus 7 ± 2 days, P = 0.03). Three of those four patients had alveolar infiltrates. Conclusion Sole HMPV infection was detected in children with CAP in Salvador, North-East Brazil. HMPV may play a role in the childhood CAP burden. |
Keywords: | Acute respiratory infection Lower tract respiratory infection New respiratory virus Respiratory viral infection |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14810 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Files in This Item:
File | Description | Size | Format | |
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Cristiana M. Nascimento Carvalho.pdf | 58,31 kB | Adobe PDF | View/Open |
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