Please use this identifier to cite or link to this item:
https://repositorio.ufba.br/handle/ri/14769
metadata.dc.type: | Artigo de Periódico |
Title: | Flavonoids inhibit angiogenic cytokine production by human glioma cells |
Other Titles: | Phytotherapy Research |
Authors: | Freitas, Sandra Costa, Silvia Lima Azevedo, Camila Carvalho, Gerson Freire, Songeli Barbosa, Pedro Rocha Velozo, Eudes da Silva Schaer, Robert Eduard Tardy, Marcienne Bloch Nascimento, Roberto José Meyer Nascimento, Ivana Lúcia de Oliveira |
metadata.dc.creator: | Freitas, Sandra Costa, Silvia Lima Azevedo, Camila Carvalho, Gerson Freire, Songeli Barbosa, Pedro Rocha Velozo, Eudes da Silva Schaer, Robert Eduard Tardy, Marcienne Bloch Nascimento, Roberto José Meyer Nascimento, Ivana Lúcia de Oliveira |
Abstract: | VEGF and TGF-β1 are cytokines that stimulate tissue invasion and angiogenesis. These factors are considered as molecular targets for the therapy of glioblastoma. Bevacizumab, a recombinant humanized monoclonal antibody developed against VEGF, inhibits endothelial cell proliferation and vessel formation. Flavonoids obtained from Dimorphandra mollis and Croton betulaster have been described as proliferation inhibitors of a human glioblastoma derived cell line. VEGF and TGF-β1 levels were dosed by ELISA in a GL-15 cell line treated with bevacizumab and also with the flavonoids rutin, 5-hydroxy-7,4′-dimethoxyflavone, casticin, apigenin and penduletin. Rutin reduced the VEGF and TGF-β1 levels after 24 h but not after 72 h. The other flavonoids significantly reduced TGF-β1 production. Bevacizumab reduced only the VEGF levels in the supernatant from GL-15 cultures. These results suggest that the flavonoids studied, and commonly used in popular medicine, present an interesting subject of study due to their potential effect as angiogenic factor inhibitors. |
Keywords: | Angiogenesis Angiogenic factor inhibitors Flavonoids VEGF TGF-β1 Glioblastoma |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14769 |
Issue Date: | 2011 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
Files in This Item:
File | Description | Size | Format | |
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Sandra Freitas.pdf | 597,2 kB | Adobe PDF | View/Open |
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