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https://repositorio.ufba.br/handle/ri/14627
metadata.dc.type: | Artigo de Periódico |
Título : | Epidemiological methods in diarrhoea studies—an update |
Otros títulos : | International Journal of Epidemiology |
Autor : | Schmidt, Wolf Peter Arnold, Benjamin F. Boisson, Sophie Genser, Bernd Luby, Stephen P. Barreto, Mauricio Lima Clasen, Thomas Cairncross, Sandy |
metadata.dc.creator: | Schmidt, Wolf Peter Arnold, Benjamin F. Boisson, Sophie Genser, Bernd Luby, Stephen P. Barreto, Mauricio Lima Clasen, Thomas Cairncross, Sandy |
Resumen : | Background Diarrhoea remains a leading cause of morbidity and mortality but is difficult to measure in epidemiological studies. Challenges include the diagnosis based on self-reported symptoms, the logistical burden of intensive surveillance and the variability of diarrhoea in space, time and person. Methods We review current practices in sampling procedures to measure diarrhoea, and provide guidance for diarrhoea measurement across a range of study goals. Using 14 available data sets, we estimated typical design effects for clustering at household and village/neighbourhood level, and measured the impact of adjusting for baseline variables on the precision of intervention effect estimates. Results Incidence is the preferred outcome measure in aetiological studies, health services research and vaccine trials. Repeated prevalence measurements (longitudinal prevalence) are appropriate in high-mortality settings where malnutrition is common, although many repeat measures are rarely useful. Period prevalence is an inadequate outcome if an intervention affects illness duration. Adjusting point estimates for age or diarrhoea at baseline in randomized trials has little effect on the precision of estimates. Design effects in trials randomized at household level are usually <2 (range 1.0–3.2). Design effects for larger clusters (e.g. villages or neighbourhoods) vary greatly among different settings and study designs (range 0.1–25.8). Conclusions Using appropriate sampling strategies and outcome measures can improve the efficiency, validity and comparability of diarrhoea studies. Allocating large clusters in cluster randomized trials is compromized by unpredictable design effects and should be carried out only if the research question requires it. |
Palabras clave : | Diarrhoea Cluster randomized trial Sampling Methods |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/14627 |
Fecha de publicación : | 2011 |
Aparece en las colecciones: | Artigo Publicado em Periódico Estrangeiro (ISC) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Wolf-Peter Schmidt.pdf | 205,92 kB | Adobe PDF | Visualizar/Abrir |
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