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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14581
Tipo: Artigo de Periódico
Título: Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: The 4D study
Título(s) alternativo(s): Atherosclerosis
Autor(es): Genser, Bernd
Hoffmann, Michael M.
März, Winfried
Drechsler, Christiane
Wanner, Christoph
Autor(es): Genser, Bernd
Hoffmann, Michael M.
März, Winfried
Drechsler, Christiane
Wanner, Christoph
Abstract: Aims We investigated whether KIF6 Trp719Arg genotypes affect cardiovascular outcomes and efficacy of statin therapy in patients with type 2 diabetes mellitus undergoing hemodialysis. Methods and results We conducted a post hoc analysis of the 4D-study, a randomized trial including 1255 patients. Patients were randomly assigned to double-blind treatment with either 20 mg of atorvastatin (n = 619) or placebo (n = 636) once daily and followed for 4 years (median). DNA was available for 1232 patients and we assessed KIF6 Trp719Arg genotypes by PCR and subsequent restriction digest. Carriers of the Arg719 allele showed no increased prevalence of cardiovascular disease. The incidence of cardiac death, MI, and stroke did not differ across KIF6 genotypes, irrespective of whether the patients were treated with atorvastatin or not. Conclusion In patients with type 2 diabetes mellitus on hemodialysis, KIF6 Trp719Arg genotypes were not associated with adverse cardiovascular outcomes during follow-up or with the efficacy of atorvastatin therapy.
Palavras-chave: KIF6
Pharmacogenetic
Statin treatment
Coronary artery disease
Type 2 diabetes mellitus
Hemodialysis
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/14581
Data do documento: 2011
Aparece nas coleções:Artigo Publicado em Periódico Estrangeiro (ISC)

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