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metadata.dc.type: | Artigo de Periódico |
Title: | Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni |
Other Titles: | Journal of Infectious Diseases |
Authors: | Silva, Angela Jesus, Amelia Ribeiro de Santana, Luciana B. Magalhães, Andrea Jesus, Adriana Almeida de Almeida, Roque Pacheco de Rêgo, Marco Antônio Vasconcelos Burattini, Marcelo Nascimento Pearce, Edward J. Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Silva, Angela Jesus, Amelia Ribeiro de Santana, Luciana B. Magalhães, Andrea Jesus, Adriana Almeida de Almeida, Roque Pacheco de Rêgo, Marco Antônio Vasconcelos Burattini, Marcelo Nascimento Pearce, Edward J. Carvalho Filho, Edgar Marcelino de |
Abstract: | Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)–α, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean±SD, 7.8±7.6 μg Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean ± SD) of TNF-α (1349.3±767.6 pg/mL), interleukin (IL)–1 (2683±1270 pg/mL), and IL-6 (382 ± 52.3 pg/mL) were elevated in PBMC. Serum TNF-α levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-γ levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis. |
Keywords: | Esquistossomose Esquistossomose mansoni |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14550 |
Issue Date: | 2002 |
Appears in Collections: | Artigo Publicado em Periódico (ICS) |
Files in This Item:
File | Description | Size | Format | |
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Angela Silva.pdf | 146,64 kB | Adobe PDF | View/Open |
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