Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/14506
metadata.dc.type: Artigo de Periódico
Title: Effects of acute heat exposure on prosencephalic c-Fos expression in normohydrated, water-deprived and salt-loaded rats
Other Titles: Brain Research
Authors: Santana, Rejane
Silva, Emilio de Castro e
Oliveira, Irismar Reis de
Fregoneze, Josmara B.
metadata.dc.creator: Santana, Rejane
Silva, Emilio de Castro e
Oliveira, Irismar Reis de
Fregoneze, Josmara B.
Abstract: n the present study, the distribution pattern of c-Fos protein immunoreactivity (Fos-IR) in prosencephalic areas of the brain involved in thermoregulatory and osmoregulatory responses was investigated, in rats exposed or not exposed to a hyperthermic environment, under three different conditions: normohydration, dehydration induced by water deprivation and hyperosmolarity induced by an acute intragastric salt load. Normohydrated, water-deprived or salt-loaded male Wistar rats (270 ± 30 g) were submitted or not to acute heat exposure (33 °C for 45 min). A separate group of animals was submitted to the same experimental protocol and had blood samples collected before and after the heating period to measure serum osmolarity and sodium. The brains were processed for c-Fos immunohistochemistry using the avidin–biotin peroxidase method. After analyzing Fos-IR in the brains of animals in the present study, three different types of prosencephalic areas were identified: (1) those that respond to hydrational and to heat conditions, with an interaction between these two factors (PaMP and SON); (2) those that respond to hydrational and to heat conditions, but with no interaction between these factors (MnPO, LSV and OVLT); and (3) those that respond only to hydrational status (SFO and PaLM).
Keywords: Thermoregulation
Hyperthermia
Dehydration
Hyperosmolarity
metadata.dc.rights: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/14506
Issue Date: 2007
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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