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https://repositorio.ufba.br/handle/ri/14455| Tipo: | Artigo de Periódico |
| Título: | Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets |
| Título(s) alternativo(s): | Bioorganic and Medicinal Chemistry |
| Autor(es): | Peixinho, Solange Villar, Rosa M. Longo, José Gil Daranas, Antonio H. Souto, Marı́a L. Fernández, José J. Barral, Miguel A. Santafé, Gilmar Rodrı́guez, Jaime Jiménez, Carlos |
| Autor(es): | Peixinho, Solange Villar, Rosa M. Longo, José Gil Daranas, Antonio H. Souto, Marı́a L. Fernández, José J. Barral, Miguel A. Santafé, Gilmar Rodrı́guez, Jaime Jiménez, Carlos |
| Abstract: | Ten zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthus nymphaeus and Zoanthus sp.) along with one semisynthetic derivative were evaluated for their antiplatelet activities on human platelet aggregation induced by several stimulating agents. 11-Hydroxyzoanthamine (11) and a synthetic derivative of norzoanthamine (16) showed strong inhibition against thrombin-, collagen- and arachidonic acid-induced aggregation, zoanthenol (15) displayed a selective inhibitory activity induced by collagen, while zoanthaminone (10) behaved as a potent aggregant agent. These evaluations allowed us to deduce several structure–activity relationships and suggest some mechanisms of action for this type of compounds. |
| Palavras-chave: | Alcalóides |
| Tipo de Acesso: | Acesso Aberto |
| URI: | http://repositorio.ufba.br/ri/handle/ri/14455 |
| Data do documento: | 2003 |
| Aparece nas coleções: | Artigo Publicado em Periódico (Biologia) |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Solange Peixinho.pdf | 229,6 kB | Adobe PDF | Visualizar/Abrir |
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