1. Universidade Federal da Bahia
  2. Instituto de Biologia - IBIO
  3. Artigo Publicado em Periódico (Biologia)
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14455
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorPeixinho, Solange-
dc.contributor.authorVillar, Rosa M.-
dc.contributor.authorLongo, José Gil-
dc.contributor.authorDaranas, Antonio H.-
dc.contributor.authorSouto, Marı́a L.-
dc.contributor.authorFernández, José J.-
dc.contributor.authorBarral, Miguel A.-
dc.contributor.authorSantafé, Gilmar-
dc.contributor.authorRodrı́guez, Jaime-
dc.contributor.authorJiménez, Carlos-
dc.creatorPeixinho, Solange-
dc.creatorVillar, Rosa M.-
dc.creatorLongo, José Gil-
dc.creatorDaranas, Antonio H.-
dc.creatorSouto, Marı́a L.-
dc.creatorFernández, José J.-
dc.creatorBarral, Miguel A.-
dc.creatorSantafé, Gilmar-
dc.creatorRodrı́guez, Jaime-
dc.creatorJiménez, Carlos-
dc.date.accessioned2014-01-23T18:12:20Z-
dc.date.issued2003-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/14455-
dc.descriptionTexto completo: acesso restrito. p. 2301–2306pt_BR
dc.description.abstractTen zoanthamine-type alkaloids from two marine zoanthids belonging to the Zoanthus genus (Zoanthus nymphaeus and Zoanthus sp.) along with one semisynthetic derivative were evaluated for their antiplatelet activities on human platelet aggregation induced by several stimulating agents. 11-Hydroxyzoanthamine (11) and a synthetic derivative of norzoanthamine (16) showed strong inhibition against thrombin-, collagen- and arachidonic acid-induced aggregation, zoanthenol (15) displayed a selective inhibitory activity induced by collagen, while zoanthaminone (10) behaved as a potent aggregant agent. These evaluations allowed us to deduce several structure–activity relationships and suggest some mechanisms of action for this type of compounds.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0968-0896(03)00107-Xpt_BR
dc.subjectAlcalóidespt_BR
dc.titleEvaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human plateletspt_BR
dc.title.alternativeBioorganic and Medicinal Chemistrypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 11, n. 10pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (Biologia)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Solange Peixinho.pdf229,6 kBAdobe PDFVisualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.