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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14412
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dc.contributor.authorCastilho, Marcelo Santos-
dc.contributor.authorGuido, Rafael V. C.-
dc.contributor.authorAndricopulo, Adriano D.-
dc.creatorCastilho, Marcelo Santos-
dc.creatorGuido, Rafael V. C.-
dc.creatorAndricopulo, Adriano D.-
dc.date.accessioned2014-01-21T20:58:37Z-
dc.date.issued2007-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/14412-
dc.descriptionTexto completo: acesso restrito. p. 6242-6252pt_BR
dc.description.abstractCoronary heart disease (CHD) is one of the major causes of human death. The most successful therapeutic approach available is based on the reduction of low density-lipoprotein cholesterol (LDL-C). However, it is believed that the next paradigm in CHD treatment will rely on increased HDL-C levels. One of the most promising strategies for this goal is the inhibition of cholesteryl ester transfer protein (CETP). In the present work, robust classical 2D QSAR (r2 = 0.76, q2 = 0.72) and hologram QSAR (r2 = 0.88, q2 = 0.70) models were developed for a series of 85 CETP inhibitors (N-N-disubstituted trifluoro-3-amino-2-propanol derivatives). These models are complementary in nature and highlight important structural features for the design of novel CETP inhibitors with improved potency.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/10.1016/j.bmc.2007.06.021pt_BR
dc.subjectQSARpt_BR
dc.subjectCoronary heart diseasept_BR
dc.subjectTrifluoro-3-amino-2-propanol derivativespt_BR
dc.subjectCETPpt_BR
dc.subjectInhibitorspt_BR
dc.subjectCoronariopatiaspt_BR
dc.title2D Quantitative structure–activity relationship studies on a series of cholesteryl ester transfer protein inhibitorspt_BR
dc.title.alternativeBioorganic and Medicinal Chemistrypt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 15, n. 18pt_BR
dc.embargo.liftdate10000-01-01-
Aparece nas coleções:Artigo Publicado em Periódico (FAR)

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