https://repositorio.ufba.br/handle/ri/14352
Tipo: | Artigo de Periódico |
Título: | α-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis |
Título(s) alternativo(s): | Clinical & Laboratory Haematology |
Autor(es): | Gonçalves, M. de Souza Couto, Fábio David Albuquerque, Arlete Barreto Lins de Adorno, Elisângela Vitória Moura Neto, José Pereira de Abbehusen, Luciana de Freitas Oliveira, J. L. B. de Reis, M. G. dos |
Autor(es): | Gonçalves, M. de Souza Couto, Fábio David Albuquerque, Arlete Barreto Lins de Adorno, Elisângela Vitória Moura Neto, José Pereira de Abbehusen, Luciana de Freitas Oliveira, J. L. B. de Reis, M. G. dos |
Abstract: | α-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. α-thalassemia-23.7kb (α-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women – 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were α-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal α genes and those with α-Thal23.7kb (P = 0.031). Statistical analysis of AC group patients with normal α genes and α-Thal23.7kb carriers showed differences in MCV (P = 0.001); MCH (P = 0.003) and Hb C concentrations (P = 0.011). Analysis of AA and AC group patients with normal α genes showed differences in RBC (P = 0.033), Hb concentration (P = 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the α-Thal23.7kb genotype. The AC α-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns. |
Palavras-chave: | Hemoglobinopathies Hemoglobin C Pregnancy Thalassemia Hematologic parameters |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14352 |
Data do documento: | 2003 |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
Arquivo | Descrição | Tamanho | Formato | |
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M. De Souza Gonçalves.pdf | 176,52 kB | Adobe PDF | Visualizar/Abrir |
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