Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/13912
metadata.dc.type: Artigo de Periódico
Title: Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin
Other Titles: Journal of Medical Virology
Authors: Mello, Vivianne Barretto de
Cruz, Thomaz Rodrigues Porto da
Nuñez, Geila Ribeiro
Simões, Maria Tereza
Braga, Hélio Jose Vieira
Araújo, César
Cunha, Simone Muniz Carvalho Fernandes da
Schinoni, Maria Isabel
Cruz, Marla
Paraná, Raymundo
metadata.dc.creator: Mello, Vivianne Barretto de
Cruz, Thomaz Rodrigues Porto da
Nuñez, Geila Ribeiro
Simões, Maria Tereza
Braga, Hélio Jose Vieira
Araújo, César
Cunha, Simone Muniz Carvalho Fernandes da
Schinoni, Maria Isabel
Cruz, Marla
Paraná, Raymundo
Abstract: Patients with hepatitis C virus (HCV) infection present higher risk of developing type-2 diabetes mellitus (DM). However, the mechanism of this association and the role of antiviral treatment are still unclear. The objective of this study was to investigate the relationship between the use of peguilated interferon and the development of insulin resistance (IR) in these patients. Methods: HOMA index was evaluated in 30 HCV-infected patients just before and during the first 6 months of treatment with peguilated interferon plus ribavirin. Anthropometrical parameters and glucose/cholesterol profile were also monitored. Results: No changes in HOMA after 6 months of treatment were observed. Glucose levels decreased but not significantly (P = 0.059). Patients with higher HOMA index after 6 months of treatment also presented higher aminotransferase levels (P = 0.03), higher fat index on computed tomography (P = 0.011), longer time of exposure to the virus (P = 0.021), and a positive smoking history when compared to non-insulin resistant patients (P = 0.045). There was no influence of fibrosis stage on liver biopsy in the insulin-resistance development. Conclusions: No changes in the IR were observed after 6 months of treatment. Insulin resistance is related to the abdominal fat and anthropometrical parameters rather than to the antiviral treatment. J. Med.
Keywords: Interferon
Peripheral insulin resistance
Virus c hepatitis
Diabetes mellitus
metadata.dc.rights: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13912
Issue Date: 2006
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Medicina)

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