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https://repositorio.ufba.br/handle/ri/13897
metadata.dc.type: | Artigo de Periódico |
Título : | Polymorphism of Cytokine Genes (TGF-[beta]1, IFN-[gamma], IL-6, IL-10, and TNF-[alpha]) in Patients With Chronic Pancreatitis |
Otros títulos : | Pancreas |
Autor : | Bendicho, Maria Teresita Del Niño Jesus Fernandez Guedes, Jorge Carvalho Silva, Naize Nara Pinheiro da Santana, Genoile Oliveira Santos, Raquel Rocha dos Lyra, André Castro Lyra, Luiz Guilherme Costa Nascimento, Roberto José Meyer Lemaire, Denise Carneiro |
metadata.dc.creator: | Bendicho, Maria Teresita Del Niño Jesus Fernandez Guedes, Jorge Carvalho Silva, Naize Nara Pinheiro da Santana, Genoile Oliveira Santos, Raquel Rocha dos Lyra, André Castro Lyra, Luiz Guilherme Costa Nascimento, Roberto José Meyer Lemaire, Denise Carneiro |
Resumen : | Objectives: The polymorphisms in cytokine genes have allowed for the understanding of the genetic determinants of diseases. The aims of this study were to describe and compare the frequencies of polymorphisms on the interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-[alpha], transforming growth factor (TGF)-[beta]1, and interferon (IFN)-[gamma] genes between patients with chronic pancreatitis (CP) and healthy individuals from Bahia, Brazil. Methods: Twenty-eight individuals were evaluated at a university gastroenterology outpatient service (4 women and 24 men), all diagnosed with CP based on clinical and radiologic aspects. The control group was composed of 94 (11 women and 83 men) blood donors. The polymorphisms studied were TNF-[alpha] (-308G/A), TGF-[beta]1 (codon 10C/T, codon 25C/G), IL-10 (-1082A/G; -819T/C; -592A/C), IL-6 (-174G/C), and IFN-[gamma] (+874T/A). Results: A statistically significant difference was observed in the frequency of the polymorphisms between the group of patients with CP and the group of healthy individuals with the polymorphism of the TGF-[beta]1 gene on codon 10. No statistically significant differences were found for the allele and genotypic frequencies on the genes that code TNF-[alpha], IFN-[gamma], IL-10, and TGF-[beta]1 codon 25, and IL-6 between the control and case groups. Conclusion: The genotypes corresponding to the high TGF-[beta]1 producer phenotypes can be associated with the fibrogenesis shown with CP. |
Palabras clave : | Chronic Pancreatitis Cytokines Genetic polymorphism Transforming growth factor-b1 |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/13897 |
Fecha de publicación : | 2005 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Bendicho, Maria Teresita.pdf | 78,98 kB | Adobe PDF | Visualizar/Abrir |
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