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metadata.dc.type: | Artigo de Periódico |
Title: | Circulation of 3 lineages of a novel saffold cardiovirus in humans |
Other Titles: | Emerging Infectious Diseases |
Authors: | Drexler, Jan Felix Luna, Luciano Kleber de Souza Stöcker, Andreas Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Pedroso, Célia Ribeiro, Hugo da Costa |
metadata.dc.creator: | Drexler, Jan Felix Luna, Luciano Kleber de Souza Stöcker, Andreas Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Pedroso, Célia Ribeiro, Hugo da Costa |
Abstract: | Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis–like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients <6 years of age. Viral loads were 283,305–5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%–77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified. |
metadata.dc.publisher.country: | Brasil |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13887 |
Issue Date: | 2008 |
Appears in Collections: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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