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https://repositorio.ufba.br/handle/ri/13769
metadata.dc.type: | Artigo de Periódico |
Título : | Identification of paramyosin T cell epitopes associated with human resistance to Schistosoma mansoni reinfection |
Otros títulos : | Clinical and Experimental Immunology |
Autor : | Jesus, A. R. de Carvalho Filho, Edgar Marcelino de Fonseca, C. T. Cunha-Neto, E. Goldberg, A. C. Kalil, J. Oliveira, R. Correa Hammer, J. Sidney, J. Sette, A. Oliveira, S. C. |
metadata.dc.creator: | Jesus, A. R. de Carvalho Filho, Edgar Marcelino de Fonseca, C. T. Cunha-Neto, E. Goldberg, A. C. Kalil, J. Oliveira, R. Correa Hammer, J. Sidney, J. Sette, A. Oliveira, S. C. |
Resumen : | Paramyosin, a Schistosoma mansoni myoprotein associated with human resistance to infection and reinfection, is a candidate antigen to compose a subunit vaccine against schistosomiasis. In this study, 11 paramyosin peptides selected by TEPITOPE algorithm as promiscuous epitopes were produced synthetically and tested in proliferation and in vitro human leucocyte antigen (HLA)-DR binding assays. A differential proliferative response was observed in individuals resistant to reinfection compared to individuals susceptible to reinfection in response to Para (210–226) peptide stimulation. In addition, this peptide was able to bind to all HLA-DR molecules tested in HLA-DR binding assays, confirming its promiscuity. Para (6–22) and Para (355–371) were also shown to be promiscuous peptides, because they were able to bind to the six and eight most prevalent HLA-DR alleles used in HLA-DR binding assays, respectively, and were also recognized by T cells of the individuals studied. These results suggest that these paramyosin peptides are promising antigens to compose an anti-schistosomiasis vaccine. |
Palabras clave : | Paramyosin Schistosoma mansoni Synthetic peptides T cells Vaccine |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/13769 |
Fecha de publicación : | 2005 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Biologia) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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j.1365-2249.2005.02941.x.pdf | 174,75 kB | Adobe PDF | Visualizar/Abrir |
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