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metadata.dc.type: | Artigo de Periódico |
Title: | Antimycobacterial brominated metabolites from two species of marine sponges |
Other Titles: | Planta Medica |
Authors: | Peixinho, Solange Oliveira, Maria Fernanda de Oliveira, Jaine Honorata Hortolan Luis de Galetti, Fabio Cícero de Sá Souza, Ana Olívia de Silva, Célio Lopes Hajdu, Eduardo Berlinck, Roberto Gomes de Souza |
metadata.dc.creator: | Peixinho, Solange Oliveira, Maria Fernanda de Oliveira, Jaine Honorata Hortolan Luis de Galetti, Fabio Cícero de Sá Souza, Ana Olívia de Silva, Célio Lopes Hajdu, Eduardo Berlinck, Roberto Gomes de Souza |
Abstract: | A screening of 500 crude extracts of marine invertebrates against the growth of Mycobacterium tuberculosis H37Rv yielded MeOH extracts of the sponges Aplysina cauliformis and Pachychalina sp. with significant activity. Further bioassay-guided fractionation of both crude extracts led to the isolation of four bromine-containing metabolites. The known (+)-fistularin-3 (1) and 11-deoxyfistularin-3 (2), and the new compound 2-(3-amino-2,4-dibromo-6-hydroxyphenyl)acetic acid (3) were isolated from the sponge A. cauliformis, while the new bromotyrosine-derived 3-(3,5-dibromo-4-methoxyphenyl)-2-methoxy-N-methylpropan-1-ammonium (4) was isolated from Pachychalina sp. Compound 4 exhibited weak antimycobacterial activity while compounds 1 - 3 displayed activity against Mycobacterium tuberculosis H37Rv, with MICs of 7.1, 7.3 and 49 μM, respectively. Compounds 1 and 2 also exhibited low cytotoxicity against J744 macrophages, indicating that both 1 and 2 are interesting leads for the development of new anti-tuberculosis agents. |
Keywords: | Antimycobacterial Marine sponge Aplysina cauliformis Pachychalina sp Bromotyrosine-derived alkaloids |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13768 |
Issue Date: | 2006 |
Appears in Collections: | Artigo Publicado em Periódico (Biologia) |
Files in This Item:
File | Description | Size | Format | |
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s-2005-916239.pdf | 109,68 kB | Adobe PDF | View/Open |
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