Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/13768
metadata.dc.type: Artigo de Periódico
Title: Antimycobacterial brominated metabolites from two species of marine sponges
Other Titles: Planta Medica
Authors: Peixinho, Solange
Oliveira, Maria Fernanda de
Oliveira, Jaine Honorata Hortolan Luis de
Galetti, Fabio Cícero de Sá
Souza, Ana Olívia de
Silva, Célio Lopes
Hajdu, Eduardo
Berlinck, Roberto Gomes de Souza
metadata.dc.creator: Peixinho, Solange
Oliveira, Maria Fernanda de
Oliveira, Jaine Honorata Hortolan Luis de
Galetti, Fabio Cícero de Sá
Souza, Ana Olívia de
Silva, Célio Lopes
Hajdu, Eduardo
Berlinck, Roberto Gomes de Souza
Abstract: A screening of 500 crude extracts of marine invertebrates against the growth of Mycobacterium tuberculosis H37Rv yielded MeOH extracts of the sponges Aplysina cauliformis and Pachychalina sp. with significant activity. Further bioassay-guided fractionation of both crude extracts led to the isolation of four bromine-containing metabolites. The known (+)-fistularin-3 (1) and 11-deoxyfistularin-3 (2), and the new compound 2-(3-amino-2,4-dibromo-6-hydroxyphenyl)acetic acid (3) were isolated from the sponge A. cauliformis, while the new bromotyrosine-derived 3-(3,5-dibromo-4-methoxyphenyl)-2-methoxy-N-methylpropan-1-ammonium (4) was isolated from Pachychalina sp. Compound 4 exhibited weak antimycobacterial activity while compounds 1 - 3 displayed activity against Mycobacterium tuberculosis H37Rv, with MICs of 7.1, 7.3 and 49 μM, respectively. Compounds 1 and 2 also exhibited low cytotoxicity against J744 macrophages, indicating that both 1 and 2 are interesting leads for the development of new anti-tuberculosis agents.
Keywords: Antimycobacterial
Marine sponge
Aplysina cauliformis
Pachychalina sp
Bromotyrosine-derived alkaloids
metadata.dc.rights: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13768
Issue Date: 2006
Appears in Collections:Artigo Publicado em Periódico (Biologia)

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