https://repositorio.ufba.br/handle/ri/13749
Tipo: | Artigo de Periódico |
Título: | Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis |
Título(s) alternativo(s): | Clinical and Experimental Immunology |
Autor(es): | Nascimento, M. C. F. Leite Primo, Janeusa Rita Bittencourt, Achilea Candida Lisboa Siqueira, I. Oliveira, M. de Fátima Nascimento, Roberto José Meyer Schriefer, Nicolaus Albert Borges Santos, S. B. Carvalho Filho, Edgar Marcelino de |
Autor(es): | Nascimento, M. C. F. Leite Primo, Janeusa Rita Bittencourt, Achilea Candida Lisboa Siqueira, I. Oliveira, M. de Fátima Nascimento, Roberto José Meyer Schriefer, Nicolaus Albert Borges Santos, S. B. Carvalho Filho, Edgar Marcelino de |
Abstract: | Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production of proinflammatory cytokines and an increase in HTLV-1 proviral load are features of HAM/TSP, but the immunological basis of IDH has not been established. In addition to severe cutaneous manifestations, the importance of IDH relies on the observation that up to 30% of children with IDH develop HAM/TSP in childhood and adolescence. In this study we determined the immune response in patients with IDH measuring interleukin (IL)-4, IL-5, IL-10, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels as well as the HTLV-1 proviral load. Additionally, regulatory cytokines and anti-cytokines were added to cultures to evaluate the ability of these molecules to down-modulate TNF-α and IFN-γ synthesis. HTLV-1 carriers and patients with HAM/TSP served as controls. TNF-α and IFN-γ levels were higher in IDH than in HTLV-1 carriers. There was no difference in IFN-γ and TNF-α concentrations in IDH and HAM/TSP patients. There was a tendency for higher IL-4 mRNA expression and immunoglobulin E (IgE) levels in IDH than in HTLV-1 carriers, but the difference did not reach statistical significance. The HTLV-1 proviral load was significantly higher in IDH patients than in HTLV-1 carriers. IDH is characterized by an exaggerated Th1 immune response and high HTLV-1 proviral load. The similarities between the immunological response in patients with IDH and HAM/TSP and the high proviral load observed in IDH provide support that IDH is a risk factor for development of HAM/TSP. |
Palavras-chave: | Cytokines/interleukins Dermatological infections HTLV-I/II |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13749 |
Data do documento: | 2009 |
Aparece nas coleções: | Artigo Publicado em Periódico (Biologia) |
Arquivo | Descrição | Tamanho | Formato | |
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j.1365-2249.2008.03869.x.pdf | 344,92 kB | Adobe PDF | Visualizar/Abrir |
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