Campo DC | Valor | Idioma |
dc.contributor.author | Nascimento, M. C. F. | - |
dc.contributor.author | Leite Primo, Janeusa Rita | - |
dc.contributor.author | Bittencourt, Achilea Candida Lisboa | - |
dc.contributor.author | Siqueira, I. | - |
dc.contributor.author | Oliveira, M. de Fátima | - |
dc.contributor.author | Nascimento, Roberto José Meyer | - |
dc.contributor.author | Schriefer, Nicolaus Albert Borges | - |
dc.contributor.author | Santos, S. B. | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Nascimento, M. C. F. | - |
dc.creator | Leite Primo, Janeusa Rita | - |
dc.creator | Bittencourt, Achilea Candida Lisboa | - |
dc.creator | Siqueira, I. | - |
dc.creator | Oliveira, M. de Fátima | - |
dc.creator | Nascimento, Roberto José Meyer | - |
dc.creator | Schriefer, Nicolaus Albert Borges | - |
dc.creator | Santos, S. B. | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2013-11-19T20:01:13Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13749 | - |
dc.description | Texto completo: acesso restrito. p. 455-462 | pt_BR |
dc.description.abstract | Human T lymphotropic virus-type 1 (HTLV-1) is the causal agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T cell leukaemia/lymphoma and infective dermatitis associated with HTLV-1 (IDH). Over-production of proinflammatory cytokines and an increase in HTLV-1 proviral load are features of HAM/TSP, but the immunological basis of IDH has not been established. In addition to severe cutaneous manifestations, the importance of IDH relies on the observation that up to 30% of children with IDH develop HAM/TSP in childhood and adolescence. In this study we determined the immune response in patients with IDH measuring interleukin (IL)-4, IL-5, IL-10, interferon (IFN)-γ and tumour necrosis factor (TNF)-α levels as well as the HTLV-1 proviral load. Additionally, regulatory cytokines and anti-cytokines were added to cultures to evaluate the ability of these molecules to down-modulate TNF-α and IFN-γ synthesis. HTLV-1 carriers and patients with HAM/TSP served as controls. TNF-α and IFN-γ levels were higher in IDH than in HTLV-1 carriers. There was no difference in IFN-γ and TNF-α concentrations in IDH and HAM/TSP patients. There was a tendency for higher IL-4 mRNA expression and immunoglobulin E (IgE) levels in IDH than in HTLV-1 carriers, but the difference did not reach statistical significance. The HTLV-1 proviral load was significantly higher in IDH patients than in HTLV-1 carriers. IDH is characterized by an exaggerated Th1 immune response and high HTLV-1 proviral load. The similarities between the immunological response in patients with IDH and HAM/TSP and the high proviral load observed in IDH provide support that IDH is a risk factor for development of HAM/TSP. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1111/j.1365-2249.2008.03869.x | pt_BR |
dc.subject | Cytokines/interleukins | pt_BR |
dc.subject | Dermatological infections | pt_BR |
dc.subject | HTLV-I/II | pt_BR |
dc.title | Infective dermatitis has similar immunological features to human T lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis | pt_BR |
dc.title.alternative | Clinical and Experimental Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 156, n. 3 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Biologia)
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