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https://repositorio.ufba.br/handle/ri/13669
metadata.dc.type: | Artigo de Periódico |
Título : | Use of a single implant of elcometrine (ST-1435), a nonorally active progestin, as a long acting contraceptive for postpartum nursing women |
Otros títulos : | Contraception |
Autor : | Coutinho, Elsimar Metzker Athayde, Célia Maria Soares Dantas, Claudia Hirsch, Cristina Barbosa, Ione Cristina |
metadata.dc.creator: | Coutinho, Elsimar Metzker Athayde, Célia Maria Soares Dantas, Claudia Hirsch, Cristina Barbosa, Ione Cristina |
Resumen : | Because of its unique features, the contraceptive effectiveness and tolerance during breast-feeding of 16-methylene-17α-acetoxy-19-nor-4-pregnene-3,20-dione (elcometrine), delivered within a single subdermal capsule of medical grade polydimethylsiloxane, was investigated. Unlike other progestational steroids, elcometrine has no affinity for androgen and estrogen receptors and is inactive by the oral route. A total of 66 breast-feeding women receiving elcometrine by the subdermal route were enrolled in the study, and 69 women who elected to use Copper-T380 intrauterine devices (IUD) served as control subjects. The women and their infants were observed until the end of the first postpartum year. There were no significant differences in growth and development measurements among the infants in the elcometrine and control groups. The percentage of infants continuing to breast-feed at 3 and 6 months was significantly higher in the elcometrine group. There were no significant differences between the concentration of elcometrine in the mother’s blood and milk. At 75 days, blood levels of elcometrine in the infants were near the undetectable and were significantly lower than the levels in maternal blood or milk (p <0.01). In 15 of 25 infants, blood levels of elcometrine were at the limit of assay sensitivity or undetectable. Two pregnancies occurred in women using IUD, whereas none occurred in those using implants. There were menstrual bleeding irregularities in both groups. A single elcometrine capsule placed subcutaneously at 6-monthly intervals appears to be an effective method of contraception for lactating women and results in blood concentrations of nursing infants at or near undetectable levels. |
Palabras clave : | Elcometrine ST-1435 Contraception Lactation Infant development |
Editorial : | Contraception |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/13669 |
Fecha de publicación : | 1999 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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