Please use this identifier to cite or link to this item: https://repositorio.ufba.br/handle/ri/13636
metadata.dc.type: Artigo de Periódico
Title: Antimicrobial activity of Rheedia brasiliensis and 7-epiclusianone against Streptococcus mutans
Other Titles: Phytomedicine
Authors: Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
metadata.dc.creator: Almeida, Luciana Salles Branco de
Murata, Ramiro Mendonça
Yatsuda, Regiane
Santos, M. H. dos
Nagem, T. J.
Alencar, S. M.
Koo, H.
Rosalen, P. L.
Abstract: This in vitro study evaluated the antimicrobial activity of extracts obtained from Rheedia brasiliensis fruit (bacupari) and its bioactive compound against Streptococcus mutans. Hexane, ethyl-acetate and ethanolic extracts obtained (concentrations ranging from 6.25 to 800 μg/ml) were tested against S. mutans UA159 through MIC/MBC assays. S. mutans 5-days-old biofilms were treated with the active extracts (100×MIC) for 0, 1, 2, 3 and 4 h (time-kill) and plated for colony counting (CFU/ml). Active extracts were submitted to exploratory chemical analyses so as to isolate and identify the bioactive compound using spectroscopic methods. The bioactive compound (concentrations ranging from 0.625 to 80 μg/ml) was then tested through MIC/MBC assays. Peel and seed hexane extracts showed antimicrobial activity against planktonic cells at low concentrations and were thus selected for the time kill test. These hexane extracts reduced S. mutans biofilm viability after 4 h, certifying of the bioactive compound presence. The bioactive compound identified was the polyprenylated benzophenone 7-epiclusianone, which showed a good antimicrobial activity at low concentrations (MIC: 1.25–2.5 μg/ml; MBC: 10–20 μg/ml). The results indicated that 7-epiclusianone may be used as a new agent to control S. mutans biofilms; however, more studies are needed to further elucidate the mechanisms of action and the anticariogenic potential of such compound found in R. brasiliensis.
Keywords: Rheedia brasiliensis
Antimicrobial activity
7-Epiclusianone
Streptococcus mutans
metadata.dc.rights: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13636
Issue Date: 2008
Appears in Collections:Artigo Publicado em Periódico (Faculdade de Odontologia)

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