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metadata.dc.type: | Artigo de Periódico |
Title: | Structural studies of 4-aminoantipyrine derivatives |
Other Titles: | Journal of Molecular Structure |
Authors: | Cunha, Silvio do Desterro Oliveira, Shana M. Rodrigues Jr, Manoel T. Bastos, Rodrigo M. Ferrari, Jailton Oliveira, Cecília M.A. de Kato, Lucília Napolitano, Hamilton B. Vencato, Ivo Lariucci, Carlito |
metadata.dc.creator: | Cunha, Silvio do Desterro Oliveira, Shana M. Rodrigues Jr, Manoel T. Bastos, Rodrigo M. Ferrari, Jailton Oliveira, Cecília M.A. de Kato, Lucília Napolitano, Hamilton B. Vencato, Ivo Lariucci, Carlito |
Abstract: | Reaction of 4-aminoantipyrine with acetylacetone, ethyl acetoacetate, benzoyl isothiocyanate, phenyl isothiocyanate, maleic anhydride and methoxymethylene Meldrum's acid afforded a series of new antipyrine derivatives. The antibacterial activity of the synthesized compounds against Micrococcus luteus ATCC 9341, Staphilococcus aureus ATCC 29737, and Escherichia coli ATCC 8739 was evaluated and the minimal inhibitory concentration determined. Modest activity was found only to the maleamic acid obtained from the reaction of 4-aminoantipyrine and maleic anhydride. 1H NMR investigation of this maleamic acid showed that it is slowly converted to the corresponding toxic maleimide. The structures of three derivatives were determined by X-ray diffraction analysis. |
Keywords: | Enaminones Thioureas Meleimide |
metadata.dc.rights: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13542 |
Issue Date: | 2005 |
Appears in Collections: | Artigo Publicado em Periódico (Química) |
Files in This Item:
File | Description | Size | Format | |
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Silvio Cunha.pdf | 260,67 kB | Adobe PDF | View/Open |
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