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metadata.dc.type: | Artigo de Periódico |
Title: | Interleukin 17 production among patients with American cutaneous leishmaniasis |
Other Titles: | Journal of Infectious Diseases |
Authors: | Bacellar, Maria Olívia Amado Ramos Faria, Daniela Nascimento, Márcia Cardoso, Thiago M. Gollob, Kenneth John Dutra, Walderez Ornelas Scott, Phillip Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Bacellar, Maria Olívia Amado Ramos Faria, Daniela Nascimento, Márcia Cardoso, Thiago M. Gollob, Kenneth John Dutra, Walderez Ornelas Scott, Phillip Carvalho Filho, Edgar Marcelino de |
Abstract: | Interleukin 17 (IL‐17) plays a critical role in inflammation and autoimmunity. Very little is known about IL‐17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL‐17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL‐17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL‐17 and the presence of cellular inflammation at the lesion site (r2=0.86; P<.001). These data support the role of IL‐17 in the pathogenesis of the inflammatory reaction in leishmaniasis. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/13165 |
Issue Date: | 2009 |
Appears in Collections: | Artigo Publicado em Periódico (Biologia) |
Files in This Item:
File | Description | Size | Format | |
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J Infect Dis.-2009-Bacellar-75-8.pdf Restricted Access | 2,5 MB | Adobe PDF | View/Open Request a copy |
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