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metadata.dc.type: | Artigo de Periódico |
Title: | Geographic clustering of leishmaniasis in northeastern Brazil |
Other Titles: | Emerging Infectious Diseases |
Authors: | Schriefer, Nicolaus Albert Borges Guimarães, Luiz H. Machado, Paulo Roberto Lima Lessa, Marcus Lessa, Hélio Andrade Ritt, Guilherme F. Góes Neto, Aristóteles Schriefer, Ana L. F. Riley, Lee W. Carvalho Filho, Edgar Marcelino de |
metadata.dc.creator: | Schriefer, Nicolaus Albert Borges Guimarães, Luiz H. Machado, Paulo Roberto Lima Lessa, Marcus Lessa, Hélio Andrade Ritt, Guilherme F. Góes Neto, Aristóteles Schriefer, Ana L. F. Riley, Lee W. Carvalho Filho, Edgar Marcelino de |
Abstract: | To determine whether disease outcomes and clades of Leishmania braziliensis genotypes are associated, we studied geographic clustering of clades and most severe disease outcomes for leishmaniasis during 1999–2003 in Corte de Pedra in northeastern Brazil. Highly significant differences were observed in distribution of mucosal leishmaniasis versus disseminated leishmaniasis (DL) (p<0.0001). Concordance was observed between distribution of these disease forms and clades of L. braziliensis genotypes shown to be associated with these disease forms. We also detected spread of DL over this region and an inverse correlation between frequency of recent DL diagnoses and distance to a previous DL case. These findings indicate that leishmaniasis outcomes are distributed differently within transmission foci and show that DL is rapidly spreading in northeastern Brazil. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/13157 |
Issue Date: | 2009 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
Files in This Item:
File | Description | Size | Format | |
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08-0406.pdf | 613,58 kB | Adobe PDF | View/Open |
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