Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.ufba.br/handle/ri/12617
metadata.dc.type: | Artigo de Periódico |
Título : | Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10 |
Otros títulos : | European Journal of Pharmacology |
Autor : | Lima, Milena da Silva Quintans Júnior, Lucindo José Santana, Wagno Alcântara de Kaneto, Carla Martins Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
metadata.dc.creator: | Lima, Milena da Silva Quintans Júnior, Lucindo José Santana, Wagno Alcântara de Kaneto, Carla Martins Soares, Milena Botelho Pereira Villarreal, Cristiane Flora |
Resumen : | Carvacrol, a phenolic monoterpene, has been reported to possess anti-inflammatory properties. However, the mechanisms involved in its pharmacological properties are currently not well understood. In the present study, the contribution of cytokine modulation to the anti-inflammatory effects of carvacrol was investigated in a classical inflammation model: the complete Freund’s adjuvant (CFA)-induced paw inflammation in mice. The paw edema was measured using a plesthismometer. Paw tissue was removed 2 h after the inflammatory stimulus to determine the levels of prostaglandin E2 (PGE2) by enzyme immunoassay, the levels of interleukin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) by ELISA or the mRNA expression of cyclooxygenase-2 (COX-2), IL-1β, TNF-α, and IL-10 by real-time PCR. Administration of carvacrol produced anti-inflammatory effects against CFA-induced inflammation in mice. Treatment of mice with carvacrol at 50 and 100 mg/kg attenuated the paw edema and reduced the IL-1β and PGE2, but not TNF-α, local levels. Similarly, carvacrol (100 mg/kg) reduced the COX-2 and IL-1β mRNA expression. The levels of IL-10, an anti-inflammatory cytokine, and the IL-10 mRNA expression in the inflamed paw were enhanced by carvacrol. In addition, the treatment with carvacrol did not reduce the CFA-induced paw edema in IL-10 knockout mice. The present results suggest that carvacrol causes anti-inflammatory effects by reducing the production of inflammatory mediators, such as IL-1β and prostanoids, possibly through the induction of IL-10 release. |
Palabras clave : | Carvacrol Anti-inflammatory Cytokines Interleukin-10 PGE2 |
Editorial : | European Journal of Pharmacology |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/12617 |
Fecha de publicación : | 2013 |
Aparece en las colecciones: | Artigo Publicado em Periódico (FAR) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
55555555555555.pdf | 597,07 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.