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https://repositorio.ufba.br/handle/ri/12149
metadata.dc.type: | Artigo de Periódico |
Título : | Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory Allergy to Blomia tropicalis |
Otros títulos : | Current Drug Targets |
Autor : | Lima, Ana Tereza Cerqueira Neves, Neuza Maria Alcântara Carvalho, Lain Carlos Pontes de Costa, Ryan dos Santos Barbosa Filho, José Maria Piuvezam, Márcia Russo, Momtchilo Barboza, Renato Oliveira, Eduardo de Jesus Marinho, Alexsandro Figueiredo, Camila Alexandrina |
metadata.dc.creator: | Lima, Ana Tereza Cerqueira Neves, Neuza Maria Alcântara Carvalho, Lain Carlos Pontes de Costa, Ryan dos Santos Barbosa Filho, José Maria Piuvezam, Márcia Russo, Momtchilo Barboza, Renato Oliveira, Eduardo de Jesus Marinho, Alexsandro Figueiredo, Camila Alexandrina |
Resumen : | Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as “Jarrinha”or “Milona”, is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examinations demonstrating the potential of this medicinal plant as new agent for asthma treatment. |
Palabras clave : | Asthma Blomia tropicalis Cissampelos sympodialis Natural products Warifteine Cytokines |
URI : | http://www.repositorio.ufba.br/ri/handle/ri/12149 |
Fecha de publicación : | 2010 |
Aparece en las colecciones: | Artigo Publicado em Periódico (ICS) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Ana Lima.pdf Restricted Access | 868,54 kB | Adobe PDF | Visualizar/Abrir Request a copy |
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