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https://repositorio.ufba.br/handle/ri/12094
metadata.dc.type: | Artigo de Periódico |
Title: | Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion |
Other Titles: | Journal of Infectious Diseases |
Authors: | Lima, Josilene B. T. Ribeiro, Guilherme S. Cordeiro, Soraia Machado Gouveia, Edilane L. Salgado, Kaátia Reis, Mitermayer G. Ko, Albert I. Reis, Joice N. |
metadata.dc.creator: | Lima, Josilene B. T. Ribeiro, Guilherme S. Cordeiro, Soraia Machado Gouveia, Edilane L. Salgado, Kaátia Reis, Mitermayer G. Ko, Albert I. Reis, Joice N. |
Abstract: | Since the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for meningitis over an 11-year period in Salvador, Brazil. H. influenzae isolates were serotyped and analyzed by polymerase chain reaction, pulsed-field gel electrophoresis, and DNA sequencing to identify strains with a specific deletion (IS1016) in the bexA gene (IS1016-bexA). We identified 43 meningitis cases caused by non-type b H. influenzae: 28 (65%) were caused by type a (Hia), 9 (21%) were caused by noncapsulated strains, and 3 (7%) each were caused by types e and f. Hia isolates clustered in 2 clonal groups; clonal group A strains (n = 9) had the IS1016-bexA deletion. Among children <5 years of age, meningitis caused by Hia from clonal group A had higher case-fatality than meningitis caused by clonal group B. Despite small numbers, these results indicate that the presence of the IS1016-bexA deletion is associated with enhanced virulence in non-type b H. influenzae. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/12094 |
Issue Date: | 2010 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
Files in This Item:
File | Description | Size | Format | |
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J Infect Dis.-2010-Lima-1577-84.pdf Restricted Access | 1,65 MB | Adobe PDF | View/Open Request a copy |
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