Felzemburgh, Victor Araújo; https://orcid.org/0000-0002-0880-2687; http://lattes.cnpq.br/7218153676571490
Resumo:
Introduction - Treatment of the burned patient at the appropriate time prevents
the occurrence of sequelae. The use of collagen-based skin substitutes can
promote a sterile wound and serve as a framework for the healing process to
occur. Objective - To evaluate tissue repair after the application of
decellularized bovine pericardium biomaterial for the treatment of cutaneous
burns. Methodology - This was an intervention study on experimental research
with 48 rats, divided into two groups; with the experimental group being
submitted to thermal burn on the back of the animals, by the brass plate
method. After being burned, the experimental group received treatment with
decellularized bovine pericardium biomaterial. The other group received
treatment with rayon dressing soaked with petrolatum. The animals were
sacrificed and evaluated histomorphologically at the biological time intervals of
7, 15, 28 and 60 postoperative days. Results - There was formation of
granulation tissue with collagen fibers positioned in a more parallel manner and
with less leukocyte fibrin exudate in the initial period of treatment in the
experimental group. Maintenance of the biomaterial covering of the burned
tissue was observed in up to 28 days. At the end of the 60 days, the control
group presented a higher mean cicatricial contraction value when compared
with that of the experimental group. Conclusion: The biomaterial was
biocompatible, promoted the stability of the lesion and increased repair of the
cutaneous lesion caused by the burn.
