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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/7874

Title: Efficacy, acceptability, and clinical effects of a low-dose injectable contraceptive combination of dihydroxyprogesterone acetophenide and estradiol enanthate
Other Titles: Contraception
Authors: Coutinho, Elsimar Metzker
Spinola, Paulo
Tomaz, Geraldez
Morais, Kleber
Souza, Rosival Nassar de
Pinho Neto, João Sabino
Leal, Weydson de Barros
Hippolito, Silvia Bomfim
Abranches, Anthony D'Aurea
Keywords: injectable contraceptive;dihydroxyprogesterone acetophenide;estradiol enanthate
Issue Date: 2000
Abstract: A total of 1,904 women, aged 15–38, used an injectable contraceptive combination of 90 mg dihydroxyprogesterone acetophenide with 6 mg estradiol enanthate, given once during each menstrual cycle between the 7th and 10th day, and preferably on the 8th day of the cycle, for a total of 17,576 cycles. Of these 1,904 women, 1,197 completed 12 cycles of use of the injectable combination. One subject became pregnant during the trial, resulting in a cumulative pregnancy rate of 0.07%. Principal reasons for discontinuation were personal, non-medical reasons, such as lost to follow-up, no longer wished to continue, protocol violation, desire to change to another contraceptive method, moved away, or other personal reasons. Mean weight of 1,901 subjects at admission to the trial was 53.5 ± 0.2 kg and this increased to 54.3 ± 0.3 kg after 12 cycles of use. Approximately 50% of subjects experienced menstrual bleeding similar to normal throughout the study period. The most frequent menstrual abnormality was irregular bleeding, experienced by approximately one-third of subjects.
Description: Texto completo: acesso restrito. p. 277–280
URI: http://www.repositorio.ufba.br/ri/handle/ri/7874
ISSN: 0010-7824
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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