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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/7318
Tipo: Artigo de Periódico
Título: Association of Type 2 Cytokines with Hepatic Fibrosis in Human Schistosoma mansoni Infection
Título(s) alternativo(s): Infection and Immunity
Autor(es): Jesus, Amélia Ribeiro de
Magalhães, Andréa
Miranda, Delfin Gonzalez
Araujo, Maria Ilma Andrade Santos
Jesus, Adriana Almeida de
Silva, Angela
Santana, Luciana B.
Autor(es): Jesus, Amélia Ribeiro de
Magalhães, Andréa
Miranda, Delfin Gonzalez
Araujo, Maria Ilma Andrade Santos
Jesus, Adriana Almeida de
Silva, Angela
Santana, Luciana B.
Abstract: The objective of this study was to evaluate the role of cytokines in hepatic fibrosis in the prehepatosplenic and early hepatosplenic stages of schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography of 94 patients. Immunological evaluation was performed by the measurement of secreted cytokines (interleukin- 5 [IL-5], IL-10, IL-13, gamma interferon, tumor necrosis factor alpha, and transforming growth factor ) in peripheral blood mononuclear cells (PBMC) stimulated by Schistosoma mansoni antigens. Significantly,higher levels of IL-5, IL-10, and IL-13 were found in supernatants of soluble egg antigen-stimulated PBMC from subjects with degree III hepatic fibrosis compared to patients with degree I or II fibrosis. Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for 1 year following initial assessment and developed more serious fibrosis during this period. The data suggest a role for type 2 cytokines in hepatic fibrosis in human schistosomiasis mansoni.
URI: http://www.repositorio.ufba.br/ri/handle/ri/7318
Data do documento: 2004
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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