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|Title: ||Lower prevalence of reported asthma in adolescents with symptoms of rhinitis that received neonatal BCG|
|Other Titles: ||Allergy|
|Authors: ||Cunha, Sérgio Souza da|
Cruz Filho, Álvaro Augusto Souza da
Dourado, Maria Inês Costa
Barreto, Mauricio Lima
Ferreira, Leila Denise Alves
Rodrigues, L. C.
|Keywords: ||allergy;asthma;BCG vaccine;hypersensitivity;rhinitis;vaccines|
|Issue Date: ||2004|
|Abstract: ||Background: BCG is a vaccine used against tuberculosis and leprosy and is an
immunostimulant that primes TH1 lymphocytes to produce cytokines that antagonize atopy both in animal models and in man. Considering that atopy is the main risk factor for asthma, one can hypothesize that vaccination inducing TH1 responses, such as BCG, can be protective against asthma.
Methods: Objective: To estimate the association between neonatal BCG vaccination
and prevalence of asthma among adolescents. Study design: Crosssectional
study with schoolchildren aged 12–16 years. The presence of a scar compatible with BCG was used as a surrogate of neonatal vaccination. A self administered structured questionnaire was prepared based on that used by the International Study of Asthma and Allergies in Childhood. The prevalence of
asthma was categorized according to the report of lifetime wheeze, lifetime
asthma, lifetime asthma among those referring allergy and among those referring
allergy and sneezing. Results: Neonatal BCG vaccination was not associated with the overall prevalence of reported wheezing or asthma. However, in the subgroup reporting
current allergy and sneezing, neonatal BCG was associated with a 37% reduction
of prevalence of lifetime asthma.
Conclusions: In the population we surveyed, neonatal BCG scar was associated
with a reduction in the risk of asthma only in individuals with a past history
suggestive of allergic rhinitis.|
|Description: ||p. 857-862|
|Appears in Collections:||Artigos Publicados em Periódicos Nacionais (ISC)|
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