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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/6780

Title: Evaluation of the genotypic pattern of HIV-1 resistance in AIDS patients failing antiretroviral therapy
Other Titles: Brazilian Journal of Infectious Diseases
Authors: Bahia, Fabianna Márcia Maranhão
Pedroso, Célia
Martins Netto, Eduardo
Figueiredo, Ricardo
Pinto Neto, Lauro
Brites, Carlos
Keywords: HIV-1;Mutations;Resistance;Antiretrovirals
Issue Date: Aug-2004
Publisher: The Brazilian Journal of Infectious Diseases and Contexto Publishing
Abstract: We analyzed the first 96 patients tested for HIV resistance to antiretroviral therapy in three Brazilian states. The HIV-1 reverse transcriptase (RT) and protease (PR) were sequenced by using the ABI ViroSeq system. The drugs previously used for each patient were recorded and correlated with the mutations found in the samples. Viral load (VL) and CD4 count were also recorded. Only one patient had the wild type sequence. The most prevalent mutations were: 184V (59%), 41L (47.9%), 63P (53%), 215Y (50%), 36I (46%), 10I (35%), 67N (42%), 77I (37%), 90M (36%) and 210W (33%). A positive correlation between the number of previously used ARVs and the number of mutations was observed (p<0.05). Associations between mutations and ARV drugs were identified at positions 69, 118, 184 and 215 with previous exposure to NRTI, mutations at positions 98, 100, 103, 181 and 190 with previous NNRTI use and at positions 10, 20, 30, 46, 53, 54, 71, 73, 82, 84, 88 and 90 with previous PI therapy (p<0.05). Previous exposure to ARV drugs was associated with previous genotypic resistance to specific drugs, leading to treatment failure in HIV patients. Genotypic resistance was clearly associated with virological and immunological failure.
Description: p.281-289
URI: http://www.repositorio.ufba.br/ri/handle/ri/6780
ISSN: 1413-8670
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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